Ergot: from witchcraft to biotechnology
نویسندگان
چکیده
منابع مشابه
Ergot alkaloids: From witchcraft till in silico analysis. Multi-receptor analysis of ergotamine metabolites
The term Ergot is referred to the sclerotium of ascomycetes - a protective kernel produced during resting stage of some fungi - which replaces seeds of susceptible cereals and plants intended for human and animal diet. It contains various composition of tryptophan-derived toxins defined ergot alkaloids. Since sclerotia can be harvested and milled together with cereals, they represent a source o...
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The common use of Agrobacterium as a gene vector for plants has somewhat ob-scured the fact that this bacterium remains an important plant pathogen. Pathogenic strainsof the genus Agrobacterium cause unorganized tissue growth called crown gall or profuseabnormal root development called hairy root. Agrobacterium tumefaciens induces galls onroots and crowns of several fruit and fo...
متن کاملHistory of ergot alkaloids from ergotism to ergometrine.
Epidemics of ergotism occurred frequently in the Middle Ages. They were a source of inspiration for artists and were popularly known as 'St. Anthony's Fire', resulting in gangrene, neurological diseases and death. It was caused by eating rye bread contaminated with the fungus claviceps purpurea. In 1582 it was described that a delivery could be hastened by administering a few spurs of the secal...
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Recent advances in molecular and structural biology have improved the availability of virtually any biocatalyst in large quantity and have also provided an insight into the detailed structure-function relationships of many of them. These results allowed the rational exploitation of biocatalysts for use in organic synthesis. In this context, extremophilic enzymes are extensively studied for thei...
متن کاملSynthesis of Ergot Alkaloids from Tryptophan
The first total syntheses of lysergine and setoclavine are described, as well as a new and efficient synthesis of lysergic acid. The starting material for these syntheses is tryptophan, protected as its dihydro, dibenzoyl derivative. This material is dehydrated to the corresponding azlactone, which undergoes stereoselective intramolecular Friedel-Crafts acylation to give a tricyclic ketone inte...
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ژورنال
عنوان ژورنال: Molecular Plant Pathology
سال: 2009
ISSN: 1464-6722,1364-3703
DOI: 10.1111/j.1364-3703.2009.00548.x